Titanium dioxide nanoparticles (TiO2NPs) and ascorbic acid (AsA) have been shown to enhance plant productivity. However, the effects of applying a combined dose of these substances to plants under drought stress are not well understood. Therefore, this study aimed to assess the effectiveness of applying TiO2NPs (10 ppm) and AsA (50 ppm) to the leaves of coffee plants (Coffea arabica cv. Khawlani) subjected to drought conditions at 50% and 20% of their field capacity (FC). The study's findings demonstrated that coffee plants subjected to drought stress exhibited reductions in root and shoot length, as well as decreases in fresh and dry weights, relative water content (RWC), while also showing increases in proline levels, total soluble carbohydrates (TSC), malonaldehyde (MDA) content, and antioxidant activities (superoxide dismutase, SOD; activity, and catalase, CAT). However, following the application of TiO2NPs and AsA, these drought-stressed (50% and 20% FC) coffee plants displayed enhanced growth, increased RWC, and higher activities of SOD and CAT, along with decreased levels of MDA, and so on. Taken together, TiO2NPs and AsA, whether applied individually or in combination, could serve as highly effective components for promoting the development of coffee plants by enhancing their physiological functions.