Gol-e-Gohar iron complex, one the largest iron concentrate producer, is located in the Kerman Province in Iran. The ore suffers from elevated S and P content equal to 0.5% S and 0.08% P, respectively, while the steel industrial permitted limit is 0.1% S and 0.05% P. The main source of S and P are pyrite and apatite. In this work it was attempted to decrease the S and P content in concentrate using reversed flotation with xanthates, in which pyrite floated while fine apatite particles were entrained with water. The liberation degree for pyrite in the - 75+53 μm size fraction was 65%. The influecnce of such parameters as type and doze of collector, frother and depressant, solid content, pH, impeller speed, frothing time, conditioning time and desliming, on S and P removal were investigated. The best results were achieved with desliming. The collector, frother and dispersant doses were 50g/Mg of KAX, 60g/Mg of MIBC and 200g/Mg of sodium silicate at pulp pH=8 and 6 minutes of conditioning time. Under best conditions, with desliming, a concentrate with acceptable grades of Fe (70.24%), S (0.041%), and P (0.043%) were obtained. The recovery of Fe was 95.11% while sulfur removal 92.24%. The effect of different size fractions and two-stage flotation were also studied. The result showed that in +45 μm and also -38 μm size fractions, S and P contents were bellow or near the permitted limit. It was postulated that +45 μm size fraction was the most convenient for flotation while -38 μm was the best for removal with water flow. With 100 g/Mg of KAX and one-stage flotation, S content was 0.191% while in two-stage flotation it was reduced to 0.097%.