Flotation process involves aggregation of the particles based on the material/compound type of random mixtures such as ores and seawater. It is primarily used in pretreatment of water desalination and other industrial applications. The process makes use of various fluid mechanics principles as multi-fluids are involved. The multi-fluids in most of the flotation processes are of different phases, such as air and water. Like any other process, the efficiency of flotation is important, and hence most of the studies have been dedicated to understanding how the various parameters are affecting the flotation process. Among various parameters, fluids properties and flow parameters chiefly affect the flotation process. In particular, the bubble-particle interaction of the flotation process has been of interest as it is one of the cost-effective ways to enhance flotation efficiency. In this review, the authors present the latest developments in such parametric studies. This paper could be of interest to research students, academic researchers, and practitioners who want to contribute to (or take from) flotation research.