The "cliff-like" clogging in underground leaching uranium injection systems remains a critical technical challenge constraining production efficiency. Field observations indicate that fine suspended particles formed under acidic leaching conditions are the primary causative factors. This study systematically investigated the pressure variations and effluent turbidity patterns of silica fine suspended particles under different conditions (particle sizes: 1, 5, 30 um; concentrations: 200-800 mg/L; filter mesh sizes: 50-400 mesh; solution flow rates: 30-120 mL/min), as well as the migration and clogging mechanisms of silica particles. Experimental results demonstrated that when silica particle sizes exceed filter mesh openings, rapid formation of filter cakes on the surface causes abrupt pressure surges. When particle sizes approach or fall below mesh dimensions, particles gradually deposit in internal pores, leading to deep-seated clogging. While larger filter mesh sizes effectively intercept fine particles, they significantly accelerate clogging progression. Although increased flow rates temporarily delay surface clogging, they elevate the risk of particle migration into deeper ore layers. This study reveals the multi-mechanism coupling characteristics of silica particle clogging in underground leaching processes, providing theoretical and experimental foundations for optimizing injection parameters.