The problems of possible application of de-agglometration operations into industrial HPGR-based crushing circuits, were presented in the paper. The HPGR technology has the potential to provide a significant circuit efficiency increases from technological (better comminution efficiency) and economic (lower energy-consumption of crushing process) scopes. However, the HPGR product is usually compressed into a flake product, what may constitute a technical challenge in effective classification of crushing product and the overall efficiency of the circuit. Three methods of flakes disintegration were investigated in the paper: an impact de-agglomeration, drum de-agglomeration and the wet one. Results showed that the wet and drum de-agglomeration operations are the most favourable methods of flakes disintegration. Additionally the wet process is especially beneficial for material with lower moisture content.