In view of the existing double-layer linear vibrating screen, the screen surface inclination angle is basically parallel design. This paper puts forward a double-layer non-parallel and relatively independent vibrating screen. Experimental prototype of double-layer relatively independent vibrating screen under variable parameters was manufactured to verify the feasibility of simulations. This paper applied the single-factor tests to establish relationships between screening parameters of double-layer non-parallel and relatively independent vibrating screen and screening performance. What’s more, the combination of screening parameters was optimized using the response surface method (RSM). The optimal combination after the round is as follow: vibration frequency 35 Hz, the angle of eccentric block 14.2°, the inclination of the upper screen 14.6° and the inclination of the lower screen 8.8°.